Transient parametric pilot study on thermosyphon heat transport device: A computational fluid dynamics hypothesis and experimental exploration

This study aims to examine the practicality of a novel passive heat transport system “thermosyphon heat transport device” (THTD). It is a fluid-filled unit, with both source and sink amalgamated within it. A vertical tube-in-tube design has been incorporated, consisting of heat source, adiabatic height, and sink. To showcase the performance, a transient numerical analysis is performed using ANSYS Fluent, which is compared with the simple closed thermosiphon (SCT) for heat transport capability (1 kW) and different adiabatic heights (0.25, 1, and 1.5 m). Also, the influence of axial conduction is examined. The proposed Therminol VP1-based THTD has better heat transport capability over SCT due to a uniform flow pattern. Although the time response diminishes with adiabatic height, the novelty is justified as the heat gained by THTD (adiabatic height: 1.5 m) is 1.5 times more than SCT. Furthermore, the THTD performance is experimentally analyzed by varying the coolant flow rate (0.01, 0.02, and 0.03 kg/s), heat load (100−600 W), and transport distance (0.25 and 0.75 m), which yielded 80%−90% energy efficiency. As the THTD is crucial for a conceptual solar indoor cooker, the response under transient heating/cooling conditions is also investigated, which depicted 300 s for transient heating and 10−50 s for transient cooling.     

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges

Idiosyncratic drug-induced liver injury (IDILI) remains a significant problem for patients and drug development. The idiosyncratic nature of IDILI makes mechanistic studies difficult, and little is known of its pathogenesis for certain. Circumstantial evidence suggests that most, but not all, IDILI is caused by reactive metabolites of drugs that are bioactivated by cytochromes P450 and other enzymes in the liver. Additionally, there is overwhelming evidence that most IDILI is mediated by the adaptive immune system; one example being the association of IDILI caused by specific drugs with specific human leukocyte antigen (HLA) haplotypes, and this may in part explain the idiosyncratic nature of these reactions. The T cell receptor repertoire likely also contributes to the idiosyncratic nature. Although most of the liver injury is likely mediated by the adaptive immune system, specifically cytotoxic CD8+ T cells, adaptive immune activation first requires an innate immune response to activate antigen presenting cells and produce cytokines required for T cell proliferation. This innate response is likely caused by either a reactive metabolite or some form of cell stress that is clinically silent but not idiosyncratic. If this is true it would make it possible to study the early steps in the immune response that in some patients can lead to IDILI. Other hypotheses have been proposed, such as mitochondrial injury, inhibition of the bile salt export pump, unfolded protein response, and oxidative stress although, in most cases, it is likely that they are also involved in the initiation of an immune response rather than representing a completely separate mechanism. Using the clinical manifestations of liver injury from a number of examples of IDILI-associated drugs, this review aims to summarize and illustrate these mechanistic hypotheses.     

Effects of injection parameters on propagation patterns of hydrogen-fueled rotating detonation waves

Two-dimensional rotating detonation waves (RDWs) with separate injections of hydrogen and air are simulated using the Navier–Stokes equations together with a detailed chemical mechanism. The effects of injection stagnation temperature and slot width on the detonation propagation patterns are investigated. Results find that extremely high temperatures can lead to a chaotic mode in which detonation waves are generated and extinguished randomly. Increasing the slot width can reduce the number of detonation waves and finally trigger detonation quenching at a low injection stagnation temperature. But increasing the slot width can change the RDW propagation pattern from a chaotic to a stable mode under high injection temperature. Furthermore, the kinetic parameter τ (representing the chemical reactivity of the mixture) and the kinematic parameter α (representing the mixing efficiency of hydrogen and oxygen) are introduced to distinguish the RDW propagation patterns.     

Exploratory factor analysis and validity of the virtual reality symptom questionnaire and computer use survey

Abstract

The widespread use of virtual reality head-mounted-displays (HMDs) calls for a re-examination of the impact of prolonged exposure to fixed visual displays at close ocular proximity. The purpose of this study is to validate the Virtual Reality Symptoms Questionnaire (VRSQ), created to understand symptoms of prolonged HMDs use, and Computer Use Survey (CUS), created to assess general physical and visual discomfort symptoms. Participants (N?=?100) recorded their general discomfort symptoms using the CUS, performed an interactive task using a HMD for thirty minutes, and then answered the CUS again along with the VRSQ. VRSQ, analysed using an exploratory factor analysis, indicated a clear two-factor solution, and demonstrated very good internal consistency (α?=?0.873). The CUS, also analysed using an exploratory factor analysis, indicated a four-factor solution, and demonstrated good internal consistency (α?=?0.838).

Practitioner Summary: A quantitative-experimental study was conducted to explore the factor structure and validate both the Virtual Reality Symptoms Questionnaire (VRSQ), and the Computer Use Survey (CUS). Findings indicate the VRSQ and CUS are precise and accurate survey instruments for evaluating discomfort after VR-HMD use and the latter for computer use.

Abbreviations: VRSQ: virtual reality symptom questionnaire; CUS: computer use survey; OLED: organic light-emitting diode; MSQ: pensacola motion symptom questionnaire; SSQ: simulator sickness questionnaire; 3?D: three-dimensional computer generated space; VR: virtual reality; VR-HMD: virtual reality head-mounted-display; HMDs: head-mounted-displays; EFA: exploratory factor analysis     

GCAT-U-Net嵌入全局坐标注意力机制的遥感地块分割网络

遥感影像的地块背景特征复杂,当前地块分割方法不能较好地处理模糊的边缘信息,导致分割精度不理想;文章利用注意力机制处理地块特征,提出了一种基于全局坐标注意力机制的遥感地块分割网络:GCAT-U-Net;该方法在U-Net网络基础上嵌入了全局坐标注意力机制,加强了深度神经网络对于遥感影像数据中重要特征的关注度;在公开的GID数据集上的实验结果表明,文章提出的模型将准确率从0.9041提升到了0.9227,比传统U-Net网络提高了2百分点;结合特征自身重要性和特征位置信息的全局坐标注意力机制有助于更精确的目标定位,其输出相较于嵌入单一注意力机制,地块边界更为清晰,提升效果更为显著。     

MVVM 设计模式及其应用研究磁

MVVM 即 Model-View-ViewModel ，是微软 WPF 和 Silverlight 应用特有的一种界面设计模式。使用 MVVM设计模式可以帮助我们分离业务逻辑，显示逻辑和用户界面，使得我们的程序代码结构清晰，容易被阅读、测试、维护、替换、扩展和改进。论文意在通过逐层分解对 MVVM 及其应用进行研究。     

Distinguishability of interval type-2 fuzzy sets data by analyzing upper and lower membership functions

In this paper, we deal with the problem of classification of interval type-2 fuzzy sets through evaluating their distinguishability. To this end, we exploit a general matching algorithm to compute their similarity measure. The algorithm is based on the aggregation of two core similarity measures applied independently on the upper and lower membership functions of the given pair of interval type-2 fuzzy sets that are to be compared. Based on the proposed matching procedure, we develop an experimental methodology for evaluating the distinguishability of collections of interval type-2 fuzzy sets. Experimental results on evaluating the proposed methodology are carried out in the context of classification by considering interval type-2 fuzzy sets as patterns of suitable classification problem instances. We show that considering only the upper and lower membership functions of interval type-2 fuzzy sets is sufficient to (i) accurately discriminate between them and (ii) judge and quantify their distinguishability.     

An optimal motion planning method for computer-assisted surgical training

This paper focuses on the development and validation of an optimal motion planning method for computer-assisted surgical training. The context of this work is the development of new-generation systems that combine artificial intelligence and computer vision techniques in order to adjust the learning process to specific needs of a trainee, while preventing a trainee from the memorization of particular task settings. The problem described in the paper is the generation of shortest, collision-free trajectories for laparoscopic instrument movements in the rigid block world used for hand–eye coordination tasks. Optimal trajectories are displayed on a monitor to provide continuous visual guidance for optimal navigation of instruments. The key result of the work is a framework for the transition from surgical training systems in which users are dependent on predefined task settings and lack guidance for optimal navigation of laparoscopic instruments, to the so called intelligent systems that can potentially deliver the utmost flexibility to the learning process. A preliminary empirical evaluation of the developed optimal motion planning method has demonstrated the increase of total scores measured by total time taken to complete the task, and the instrument movement economy ratio. Experimentation with different task settings and the technical enhancement of the visual guidance are subjects of future research.     

Expression of Genes Controlling Unsaturated Fatty Acids Biosynthesis and Oil Deposition in Developing Seeds of Sacha Inchi (Plukenetia volubilis L.)

Sacha inchi (Plukenetia volubilis L., Euphorbiaceae) seed oil is rich in α-linolenic acid, a kind of n-3 fatty acids with many health benefits. To discover the mechanism underlying α-linolenic acid accumulation in sacha inchi seeds, preliminary research on sacha inchi seed development was carried out from one week after fertilization until maturity, focusing on phenology, oil content, and lipid profiles. The results suggested that the development of sacha inchi seeds from pollination to mature seed could be divided into three periods. In addition, investigations on the effect of temperature on sacha inchi seeds showed that total oil content decreased in the cool season, while unsaturated fatty acid and linolenic acid concentrations increased. In parallel, expression profiles of 17 unsaturated fatty acid related genes were characterized during seed development and the relationships between gene expression and lipid/unsaturated fatty acid accumulation were discussed.     

The phase structure,chain diffusion motion and local reorientation motion: C Solid-state NMR study on the highly-crystalline solid polymer electrolytes

In our previous paper, we investigated the influence of the phase structure on the polymeric chain diffusion in the complexed crystals of solid polymer electrolytes of PEO:LiAsF₆ and PEO:LiCF₃SO₃. We observed that with the increase of the crystallinity, the chain diffusion rate decreases dramatically. In this work, by employing the ¹³C CODEX NMR spectroscopy, we demonstrate that opposite to the behavior of the chain diffusion motion, the local reorientation motion of polymeric chains within the complexed crystals are greatly increased with the increase of the crystallinity, which is accompanied by the change of the phase structure. The relationship between the different molecular motions within the complexed crystals and the phase structure are discussed therefore.